Anthony Howell Selected Research

Fulvestrant (Faslodex)

9/2015	Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
9/2013	Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trial.
8/2011	Fulvestrant revisited: efficacy and safety of the 500-mg dose.
10/2010	Insights into the place of fulvestrant for the treatment of advanced endocrine responsive breast cancer.
9/2006	Pure oestrogen antagonists for the treatment of advanced breast cancer.
3/2006	Fulvestrant ('Faslodex'): current and future role in breast cancer management.
8/2005	Selective oestrogen receptor modulators, aromatase inhibitors and the female breast.
7/2005	Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials.
1/2005	Clinical development of fulvestrant ("Faslodex").
5/2004	Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial.

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Anthony Howell Research Topics

Disease

156	Breast Neoplasms (Breast Cancer) 06/2022 - 04/2002
103	Neoplasms (Cancer) 06/2022 - 10/2003
22	Neoplasm Metastasis (Metastasis) 01/2022 - 10/2003
8	Hypoxia (Hypoxemia) 01/2022 - 04/2010
8	Inflammation (Inflammations) 01/2022 - 04/2010
8	Mitochondrial Diseases (Mitochondrial Disease) 03/2013 - 04/2010
6	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2022 - 02/2005
6	Carcinogenesis 02/2013 - 09/2004
5	Weight Gain 01/2022 - 06/2007
5	Overweight 12/2021 - 07/2010
5	Starvation 11/2012 - 08/2011
4	Weight Loss (Weight Reduction) 01/2022 - 05/2012
4	Obesity 01/2022 - 01/2004
4	Ovarian Neoplasms (Ovarian Cancer) 06/2018 - 12/2010
4	Lymphatic Metastasis 04/2012 - 08/2010
3	Genetic Risk Score 01/2020 - 03/2017
3	Venous Thrombosis (Deep-Vein Thrombosis) 02/2016 - 02/2007
3	Arthralgia (Joint Pain) 12/2014 - 04/2012
3	Endometrial Neoplasms (Endometrial Cancer) 06/2012 - 10/2005
3	Lung Neoplasms (Lung Cancer) 12/2010 - 10/2005
2	Triple Negative Breast Neoplasms 06/2022 - 01/2019
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 01/2019
2	Melanoma (Melanoma, Malignant) 11/2020 - 12/2010
2	Nausea 10/2017 - 09/2013
2	Vomiting 10/2017 - 09/2013
2	Insulin Resistance 01/2016 - 05/2012
2	Communicable Diseases (Infectious Diseases) 03/2015 - 08/2013
2	Familial Breast Cancer 09/2014 - 10/2002
2	Pulmonary Embolism 06/2012 - 02/2007
2	Osteoporosis 01/2008 - 01/2004

Drug/Important Bio-Agent (IBA)

52	Tamoxifen FDA LinkGeneric 07/2021 - 04/2002
39	Anastrozole (Arimidex)FDA LinkGeneric 07/2021 - 04/2002
27	Aromatase InhibitorsIBA 11/2020 - 04/2002
24	Hormones (Hormone)IBA 01/2022 - 05/2003
23	Lactic Acid (Lactate)FDA LinkGeneric 08/2013 - 06/2010
17	KetonesIBA 01/2013 - 09/2010
15	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2008
14	Estrogen ReceptorsIBA 06/2022 - 03/2004
13	Proteins (Proteins, Gene)FDA Link 03/2022 - 04/2010
13	Fulvestrant (Faslodex)FDA Link 09/2015 - 04/2002
13	Estrogens (Estrogen)FDA Link 09/2015 - 01/2004
13	Caveolin 1IBA 11/2012 - 06/2010
12	AntioxidantsIBA 01/2013 - 09/2010
10	Progesterone Receptors (Progesterone Receptor)IBA 03/2022 - 10/2003
9	Pharmaceutical PreparationsIBA 03/2015 - 05/2004
9	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2012 - 08/2011
8	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 06/2012
7	Raloxifene Hydrochloride (Evista)FDA Link 01/2018 - 07/2003
6	exemestane (Aromasin)FDA Link 09/2014 - 05/2003
6	EnzymesIBA 01/2013 - 02/2011
6	Metformin (Glucophage)FDA LinkGeneric 01/2013 - 04/2011
6	Glutamine (L-Glutamine)FDA Link 12/2011 - 09/2010
5	Selective Estrogen Receptor Modulators (SERM)IBA 01/2016 - 03/2004
5	Ketone BodiesIBA 03/2013 - 04/2012
5	Adenosine Triphosphate (ATP)IBA 01/2013 - 06/2010
4	CarcinogensIBA 03/2013 - 09/2010
4	Chloroquine (Aralen)FDA LinkGeneric 12/2012 - 06/2010
4	PoisonsIBA 11/2012 - 04/2011
4	Letrozole (Femara)FDA LinkGeneric 06/2012 - 05/2003
3	human ERBB2 proteinIBA 01/2022 - 11/2011
3	CytokinesIBA 01/2022 - 06/2011
3	Progesterone FDA LinkGeneric 01/2021 - 09/2004
3	Biological ProductsIBA 01/2020 - 12/2016
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 09/2012
3	Insulin (Novolin)FDA Link 01/2019 - 06/2007
3	Glucose (Dextrose)FDA LinkGeneric 12/2011 - 08/2011
3	RNA (Ribonucleic Acid)IBA 12/2011 - 09/2008
3	Estrogen Receptor alphaIBA 01/2008 - 10/2003
2	Phenobarbital (Luminal)FDA Link 06/2022 - 01/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 09/2010
2	mahuang-tangIBA 01/2022 - 05/2021
2	A-Form DNA (A-DNA)IBA 01/2019 - 07/2012
2	LipidsIBA 01/2016 - 12/2012
2	Anti-Bacterial Agents (Antibiotics)IBA 03/2015 - 08/2013
2	Therapeutic UsesIBA 03/2015 - 12/2011
2	LigandsIBA 02/2013 - 08/2012
2	Cysteine (L-Cysteine)FDA Link 01/2013 - 11/2012
2	AntibodiesIBA 12/2012 - 11/2012
2	Protein Isoforms (Isoforms)IBA 09/2012 - 09/2004
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 09/2012 - 12/2011
2	Cyclin D1IBA 09/2012 - 04/2012
2	Insulin-Like PeptidesIBA 05/2012 - 06/2006
2	AmmoniaIBA 12/2011 - 07/2011
2	CatalaseIBA 08/2011 - 08/2011
2	tiboloneIBA 01/2011 - 01/2004
2	SolutionsIBA 11/2010 - 09/2010
2	Pyruvic Acid (Pyruvate)IBA 09/2010 - 06/2010
2	Diphosphonates (Bisphosphonates)IBA 01/2008 - 01/2004
2	Insulin-Like Growth Factor Binding Protein 3IBA 06/2007 - 06/2006
2	Insulin-Like Growth Factor I (IGF-1)IBA 06/2007 - 06/2006

Therapy/Procedure

66	Therapeutics 01/2022 - 04/2002
11	Drug Therapy (Chemotherapy) 01/2022 - 01/2004
7	Mastectomy (Mammectomy) 01/2022 - 07/2013
6	Chemoprevention 11/2019 - 01/2008
5	Radiotherapy 12/2010 - 10/2003
4	Aftercare (After-Treatment) 11/2020 - 10/2005
4	Ovariectomy (Oophorectomy) 06/2018 - 10/2002
3	Adjuvant Chemotherapy 06/2019 - 06/2005
3	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/2018 - 01/2004
3	Precision Medicine 01/2014 - 04/2011